Article
Genomic Loss and Epigenetic Silencing of the FOSL1 Tumor Suppressor Gene in Radiation-induced Neoplastic Transformation of Human CGL1 Cells Alters the Tumorigenic Phenotype In Vitro and In Vivo.
Radiation research - 1 Jul 2023
Pirkkanen Jake, Tharmalingam Sujeenthar, Thome Christopher, Sinex Helen Chin, Benjamin Laura V, Losch Adam C, Borgmann Anthony J, Dhaemers Ryan M, Gordon Christopher, Boreham Douglas R, Mendonca Marc S
Abstract excerpt
The CGL1 human hybrid cell system has been utilized for many decades as an excellent cellular tool for investigating neoplastic transformation. Substantial work has been done previously implicating genetic factors related to chromosome 11 to the alteration of tumorigenic phenotype in CGL1 cells. This includes candidate tumor suppressor gene FOSL1, a member of the AP-1 transcription factor complex which encodes...
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