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Article

Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene.

Oncogene - 26 Jun 2003

Kunapuli Padmaja, Chitta Kasyapa S, Cowell John K

Abstract excerpt

The leucine-rich, glioma-inactivated (LGI1) gene, located in 10q24, was originally identified because it was interrupted and inactivated by a reciprocal chromosome translocation in the T98G glioma cell line. Loss of LGI1 expression in high-grade brain tumors is correlated with the frequent loss of chromosome 10 during progression of gliomas. To investigate whether this gene can suppress the malignant phenotype in...

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Identifiers

PMID: 12821932
DOI: 10.1038/sj.onc.1206584

Genes

LGI1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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