Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene.

doi:10.1038/sj.onc.1206584

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Article

Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene.

Oncogene - 26 Jun 2003

Kunapuli Padmaja, Chitta Kasyapa S, Cowell John K

Abstract excerpt

The leucine-rich, glioma-inactivated (LGI1) gene, located in 10q24, was originally identified because it was interrupted and inactivated by a reciprocal chromosome translocation in the T98G glioma cell line. Loss of LGI1 expression in high-grade brain tumors is correlated with the frequent loss of chromosome 10 during progression of gliomas. To investigate whether this gene can suppress the malignant phenotype in...

Topics

Agar
Blotting, Western
Cell Division
Cell Membrane
Chromosomes, Human, Pair 10
Collagen
Drug Combinations
Genetic Vectors
Glioma
Humans
Intracellular Signaling Peptides and Proteins
Laminin
Leucine
Neoplasm Invasiveness
Phenotype
Proteins
Proteoglycans
Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 12821932
DOI: 10.1038/sj.onc.1206584

Genes

LGI1

Provenance

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