Article
Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma.
International journal of cancer - 15 Jul 2008
Lung Hong Lok, Lo Paulisally Hau Yi, Xie Dan, Apte Suneel S, Cheung Arthur Kwok Leung, Cheng Yue, Law Evan Wai Lok, Chua Daniel, Zeng Yi-Xin, Tsao Sai Wah, Stanbridge Eric J, Lung Maria Li
Abstract excerpt
By using a functional complementation approach, suppression of tumorigenicity was observed after transfer of intact or truncated copies of chromosome 3 into a nasopharyngeal carcinoma (NPC) HONE1 cell line. The extra exogenous chromosome 3 in the microcell hybrids (MCHs) significantly extended the lag period of tumor formation, which may be associated with loss or inactivation of wild type alleles from the normal...
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