Article
Evidence for human DNA-mediated transfer of the suppressed phenotype into malignant Chinese hamster cells.
Oncogene - 1 Dec 1991
Schäfer R, Nirkko A C, Ambühl P M, Grzeschik K H, Schwarte-Waldhoff I
Abstract excerpt
Genetic suppression of the neoplastic phenotype has been demonstrated in somatic cell hybrids between tumor and normal cells. Suppression in whole-cell and microcell hybrids cannot, as yet, be attributed to specific elements defined at the molecular level. To identify a gene capable of suppressing the neoplastic phenotype, we have introduced DNA of normal human cells into tumorigenic Chinese hamster Wg3-h-o...
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