Case-sibling studies that acknowledge unstudied parents and permit the inclusion of unmatched individuals.

Abstract excerpt

BACKGROUND: Family-based designs enable assessment of genetic associations without bias from population stratification. When parents are not readily available - especially for diseases with onset later in life - the case-sibling design, where each case is matched with one or more unaffected siblings, is useful. Analysis typically accounts for within-family dependencies by using conditional logistic regression...

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