Article
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression.
Oncogene - 16 Oct 1997
Visconti R, Cerutti J, Battista S, Fedele M, Trapasso F, Zeki K, Miano M P, de Nigris F, Casalino L, Curcio F, Santoro M, Fusco A
Abstract excerpt
We have investigated the role of the NFkappaB complex in the process of thyroid carcinogenesis by analysing thyroid carcinoma cell lines. A significant increase in p65 NFkappaB mRNA and protein expression, compared to normal thyroid cultures or tissue, was found in all of the cancer cell lines. Conversely, only a modest increase in the p50 NFkappaB mRNA and protein was found in most, but not all carcinoma cell...
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