Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The thyroid cancer PAX8-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype.

Endocrine-related cancer - 1 Oct 2013

Vu-Phan Dang, Grachtchouk Vladimir, Yu Jingcheng, Colby Lesley A, Wicha Max S, Koenig Ronald J

Abstract excerpt

A chromosomal translocation results in the production of a paired box 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARG) fusion protein (PPFP) in ∼35% of follicular thyroid carcinomas. To examine the role of PPFP in thyroid oncogenesis, the fusion protein was stably expressed in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oncogene Proteins, Fusion
Share to Paired Box Transcription Factors
Share to Pioglitazone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PPAR gamma

Share to TCF Transcription Factors

Share to Thiazolidinediones

Share to Thyroid Neoplasms

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24025583
DOI: 10.1530/ERC-13-0058
PMCID: PMC3839064

Genes

PPARG
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24025583-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The thyroid cancer PAX8-PPARG fusion protein activates Wnt/TCF-responsive cells that have a transformed phenotype.PMID 24025583Read ↗

The PAX8 / PPARγ Fusion Oncogene as a Potential Therapeutic Target in Follicular Thyroid CarcinomaSemantic proximity Read ↗

Pioglitazone Therapy of PAX8-PPARγ Fusion Protein Thyroid Carcinoma.Semantic proximity Read ↗

Detection of PAX8-PPARG fusion transcripts in archival thyroid carcinoma samples by conventional RT-PCR.Semantic proximity Read ↗

The PAX8/PPARγ fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARγ inhibitionSemantic proximity Read ↗

Evaluation of the PAX8/PPARG Translocation in Follicular Thyroid Cancer with a 4-Color Reverse-Transcription PCR Assay and Automated High-Resolution Fragment AnalysisSemantic proximity Read ↗

Identification of a paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARgamma) rearrangement mosaicism in a patient with an autonomous functioning follicular thyroid carcinoma bearing an activating mutation in the TSH receptor.Semantic proximity Read ↗

Pituitary homeobox 2 (PITX2) promotes thyroid carcinogenesis by activation of cyclin D2Semantic proximity Read ↗

Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis.Semantic proximity Read ↗

Association between Pax8-PPARandgamma;1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis.Semantic proximity Read ↗

Wnt/β-Catenin Signaling Pathway Is a Direct Enhancer of Thyroid Transcription Factor-1 in Human Papillary Thyroid Carcinoma CellsSemantic proximity Read ↗

Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells.Semantic proximity Read ↗

Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.