Article
Accumulation of allelic loss on arms of chromosomes 13q, 16q and 17p in the advanced stages of human hepatocellular carcinoma.
International journal of cancer - 30 Jul 1992
Nishida N, Fukuda Y, Kokuryu H, Sadamoto T, Isowa G, Honda K, Yamaoka Y, Ikenaga M, Imura H, Ishizaki K
Abstract excerpt
We examined loss of heterozygosity at 13 loci on 5 chromosomes in hepatocellular carcinomas (HCCs) from 56 patients. In 42 of these cases, regenerative nodules of liver cirrhosis were also analyzed. High frequencies of allelic losses were detected on chromosomes 13q (47%), 16q (40%) and 17p (64%)...
Topics
- Alleles
- Carcinoma, Hepatocellular
- Chromosome Banding
- Chromosome Deletion
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 16
- Chromosomes, Human, Pair 17
- DNA
- DNA, Neoplasm
- Female
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Male
- Neoplasm Staging