Article
Clonality analysis of multiple hepatocellular carcinomas by loss of heterozygosity pattern determined by chromosomes 16q and 13q.
Journal of gastroenterology and hepatology - 1 Apr 2005
Lin Ya-Wen, Lee Hsuan-Shu, Chen Chien-Hung, Huang Guan-Tarn, Lee Po-Huang, Sheu Jin-Chuan
Abstract excerpt
BACKGROUND AND AIM: Loss of heterozygosity (LOH) on chromosomes 16q and 13q, associated with tumor development, is frequently found in hepatocellular carcinoma (HCC). In light of this, an attempt was made to use the LOH pattern determined by microsatellite markers on 16q and 13q to discriminate clonality. METHODS: In an effort to locate the LOH region more precisely and select the appropriate markers, LOH studies...
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