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Article

Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Dec 1997

Baraban S C, Hollopeter G, Erickson J C, Schwartzkroin P A, Palmiter R D

Abstract excerpt

Neuropeptide Y (NPY) inhibits excitatory synaptic transmission in the hippocampus and is implicated in control of limbic seizures. In the present study, we examined hippocampal function and the response to pharmacologically induced seizures in mutant mice lacking this peptide. In slice electrophysiology studies, no change in normal hippocampal function was observed in NPY-deficient mice compared with normal...

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Identifiers

PMID: 9364040
PMCID: PMC6573608

Genes

NPY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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