Article
Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus.
Cell death & disease - 7 Oct 2010
Engel T, Tanaka K, Jimenez-Mateos E M, Caballero-Caballero A, Prehn J H M, Henshall D C
Abstract excerpt
The p53 tumor suppressor is a multifunctional protein, which regulates cell cycle, differentiation, DNA repair and apoptosis. Experimental seizures up-regulate p53 in the brain, and acute seizure-induced neuronal death can be reduced by genetic deletion or pharmacologic inhibition of p53. However, few long-term functional consequences of p53 deficiency have been explored. Here, we investigated the development of...
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