Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2001

Davies B, Kearns I R, Ure J, Davies C H, Lathe R

Abstract excerpt

Serine proteases in the adult CNS contribute both to activity-dependent structural changes accompanying learning and to the regulation of excitotoxic cell death. Brain serine protease 1 (BSP1)/neuropsin is a trypsin-like serine protease exclusively expressed, within the CNS, in the hippocampus and associated limbic structures. To explore the role of this enzyme, we have used gene targeting to disrupt this gene in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Excitatory Postsynaptic Potentials

Share to Kainic Acid

Share to Kallikreins

Share to Long-Term Potentiation

Share to Maze Learning

Share to Proto-Oncogene Proteins c-fos

Source

Open in PubMed Open full text

Identifiers

PMID: 11549709
PMCID: PMC6762983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity.PMID 11549709Read ↗

BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localizationSemantic proximity Read ↗

Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice.Semantic proximity Read ↗

Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) modulates neuronal death, axonal plasticity, and learning and memorySemantic proximity Read ↗

Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice.Semantic proximity Read ↗

Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic StressSemantic proximity Read ↗

Comprehensive behavioral phenotyping of calpastatin-knockout mice.Semantic proximity Read ↗

BACE Inhibitor Treatment in Mice Induces Hyperactivity in a Seizure-Related Gene 6 Family Protein Dependent Manner but Does Not alter Spatial Learning and Reference MemorySemantic proximity Read ↗

Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus.Semantic proximity Read ↗

Disruption of PLC-beta 1-mediated signal transduction in mutant mice causes age-dependent hippocampal mossy fiber sprouting and neurodegeneration.Semantic proximity Read ↗

Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations.Semantic proximity Read ↗

Galanin receptor-1 knockout mice exhibit spontaneous epilepsy, abnormal EEGs and altered inhibition in the hippocampus.Semantic proximity Read ↗

Hippocampal SPARC regulates depression-related behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.