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Article

Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments

1 Oct 1997

Abstract excerpt

The K-selective channel, TOK1, recently identified in yeast, displays the unusual structural feature of having two putative pore regions, in contrast to all previously cloned K channels. Using the TOK1 pore regions as probes, we identified a human kidney cDNA encoding a 337-amino acid protein (hKCNK1) with four transmembrane segments and two pore regions containing the signature sequence of K channels. Amino acid...

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PMID: 9362344
DOI: 10.1152/ajprenal.1997.273.4.f663

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