Article
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 1997
Furnari F B, Lin H, Huang H S, Cavenee W K
Abstract excerpt
Deletions of all or part of chromosome 10 are the most common genetic alterations in high-grade gliomas. The PTEN gene (also called MMAC1 and TEP1) maps to chromosome region 10q23 and has been implicated as a target of alteration in gliomas and also in other cancers such as those of the breast, prostate, and kidney. Here we sought to provide a functional test of its candidacy as a growth suppressor in glioma...
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