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Article

PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.

Oncogene - 8 Jul 1999

Wick W, Furnari F B, Naumann U, Cavenee W K, Weller M

Abstract excerpt

The tumor suppressor gene PTEN (MMAC1, TEP1) encodes a dual-specificity phosphatase and is considered a progression-associated target of genetic alterations in human gliomas. Recently, it has been reported that the introduction of wild type PTEN into glioma cells containing endogenous mutant PTEN alleles (U87MG, LN-308), but not in those which retain wild-type PTEN (LN-18, LN-229), causes growth suppression and...

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Source

Identifiers

PMID: 10435616
DOI: 10.1038/sj.onc.1202774

Genes

PTEN
TEP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.PMID 10435616Read ↗

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain.Semantic proximity Read ↗

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The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells.Semantic proximity Read ↗

PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.Semantic proximity Read ↗

A novel germline mutation of PTEN associated with brain tumours of multiple lineages.Semantic proximity Read ↗

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.Semantic proximity Read ↗

Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.Semantic proximity Read ↗

UVB-Induced Nuclear Translocation of PTEN Promotes Radiation Sensitivity of Human Malignant Glioma U87MG CellsSemantic proximity Read ↗

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PARP‑1 inhibition sensitizes temozolomide‑treated glioblastoma cell lines and decreases drug resistance independent of MGMT activity and PTEN proficiency.Semantic proximity Read ↗

PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.Semantic proximity Read ↗

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