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Article

Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma.

Cell death & disease - 7 Apr 2021

Choi Seung Won, Lee Yeri, Shin Kayoung, Koo Harim, Kim Donggeon, Sa Jason K, Cho Hee Jin, Shin Hye-Mi, Lee Se Jeong, Kim Hyunho, Chung Seok, Shin Jihye, Lee Cheolju, Nam Do-Hyun

Abstract excerpt

PTEN is one of the most frequently altered tumor suppressor genes in malignant tumors. The dominant-negative effect of PTEN alteration suggests that the aberrant function of PTEN mutation might be more disastrous than deletion, the most frequent genomic event in glioblastoma (GBM). This study aimed to understand the functional properties of various PTEN missense mutations and to investigate their clinical...

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Identifiers

PMID: 33828082
DOI: 10.1038/s41419-021-03657-0
PMCID: PMC8027895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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