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Article

Tenets of PTEN tumor suppression.

Cell - 2 May 2008

Salmena Leonardo, Carracedo Arkaitz, Pandolfi Pier Paolo

Abstract excerpt

Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor types. A decade of work has established that PTEN is a nonredundant phosphatase that is essential for regulating the highly oncogenic prosurvival PI3K/AKT signaling pathway. This review discusses emerging modes of PTEN function and...

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Source

Identifiers

PMID: 18455982
DOI: 10.1016/j.cell.2008.04.013

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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