Article
Rapid reversion of a deletion mutation in Moloney murine leukemia virus by recombination with a closely related endogenous provirus.
Virology - 1 Jan 1990
Martinelli S C, Goff S P
Abstract excerpt
During abortive infection of mouse cells, defective retroviruses carrying deletions in essential functions can recombine with endogenous retroviral sequences to form viable, replication-competent viruses. We have examined the reversion of a mutant Moloney murine leukemia virus with a deletion in...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- DNA Replication
- DNA, Viral
- Kinetics
- Molecular Sequence Data
- Moloney murine leukemia virus
- Mutation
- Nucleic Acid Hybridization
- Proviruses
- Recombination, Genetic
- Restriction Mapping
- Virus Replication