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Article

Rapid reversion of a deletion mutation in Moloney murine leukemia virus by recombination with a closely related endogenous provirus.

Virology - 1 Jan 1990

Martinelli S C, Goff S P

Abstract excerpt

During abortive infection of mouse cells, defective retroviruses carrying deletions in essential functions can recombine with endogenous retroviral sequences to form viable, replication-competent viruses. We have examined the reversion of a mutant Moloney murine leukemia virus with a deletion in the protease domain of the pol gene after infection of NIH/3T3 cells. In this system revertants arise quickly, only 2...

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PMID: 2294637
DOI: 10.1016/0042-6822(90)90062-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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