Article
p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2013
Nagai Yoshie, Osawa Kenji, Fukushima Hidefumi, Tamura Yukihiko, Aoki Kazuhiro, Ohya Keiichi, Yasuda Hisataka, Hikiji Hisako, Takahashi Mariko, Seta Yuji, Seo Sachiko, Kurokawa Mineo, Kato Shigeaki, Honda Hiroaki, Nakamura Ichiro, Maki Kenshi, Jimi Eijiro
Abstract excerpt
p130Cas, Crk-associated substrate (Cas), is an adaptor/scaffold protein that plays a central role in actin cytoskeletal reorganization. We previously reported that p130Cas is not tyrosine-phosphorylated in osteoclasts derived from Src-deficient mice, which are congenitally osteopetrotic, suggesting that p130Cas serves as a downstream molecule of c-Src and is involved in osteoclastic bone resorption. However, the...
Topics
- Actins
- Animals
- Bone Resorption
- Bone and Bones
- Cell Differentiation
- Crk-Associated Substrate Protein
- Guanine Nucleotide Exchange Factors
- Integrins
- Male