Article
Analysis and modulation of DNA repair in aging.
Mechanisms of ageing and development - 1 Dec 1997
Walter C A, Grabowski D T, Street K A, Conrad C C, Richardson A
Abstract excerpt
Nearly 40 years ago it was proposed that accumulation of mutations or increased levels of DNA damage might contribute to aging processes. Despite several correlative studies in this area, the answer as to whether genomic integrity contributes to aging has remained illusive. More recently it has been hypothesized that decreased mitochondrial DNA integrity plays a role in aging. To begin to test these hypotheses...
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