Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of DNA damage and repair in aging: new approaches to an old problem.

Mechanisms of ageing and development - 1 Jan 2000

Vijg Jan

Abstract excerpt

DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, various approaches have been taken to clarify the importance of preserving genome integrity for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Aging, Premature
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to Mutation

Source

Identifiers

PMID: 18394680
DOI: 10.1016/j.mad.2008.02.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of DNA damage and repair in aging: new approaches to an old problem.PMID 18394680Read ↗

DNA Damage, Aging, and CancerSemantic proximity Read ↗

Protecting the Aging Genome.Semantic proximity Read ↗

The accumulation of DNA repair defects is the molecular origin of carcinogenesis.Semantic proximity Read ↗

DNA double strand break repair, aging and the chromatin connection.Semantic proximity Read ↗

The ageing epigenome: damaged beyond repair?Semantic proximity Read ↗

Changes in DNA repair during aging.Semantic proximity Read ↗

Genome instability and aging.Semantic proximity Read ↗

Genome instability, cancer and aging.Semantic proximity Read ↗

DNA Damage and Repair: From Molecular Mechanisms to Health ImplicationsSemantic proximity Read ↗

Genome Instability and DNA Repair in Somatic and Reproductive Aging.Semantic proximity Read ↗

Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human SyndromesSemantic proximity Read ↗

Genome maintenance mechanisms are critical for preventing cancer as well as other aging-associated diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.