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Article

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1995

Han S, Hathcock K, Zheng B, Kepler T B, Hodes R, Kelsoe G

Abstract excerpt

Costimulatory interactions between T and B lymphocytes are crucial for T cell activation and B cell proliferation and differentiation. We have compared the roles of CD40L and B7-2 in the initiation and maturation of humoral immunity by administering anti-CD40 ligand (L) or anti-B7-2 Ab during the early (days -1 to 3) or late (days 6-10) phases of primary responses to thymus-dependent (Td) and -independent (Ti)...

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PMID: 7541819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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