Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

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Article

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1995

Han S, Hathcock K, Zheng B, Kepler T B, Hodes R, Kelsoe G

Abstract excerpt

Costimulatory interactions between T and B lymphocytes are crucial for T cell activation and B cell proliferation and differentiation. We have compared the roles of CD40L and B7-2 in the initiation and maturation of humoral immunity by administering anti-CD40 ligand (L) or anti-B7-2 Ab during the...

Topics

Animals
Antibodies, Monoclonal
Antibody Formation
Antigens, CD
B-Lymphocytes
B7-1 Antigen
B7-2 Antigen
Bacterial Vaccines
Base Sequence
CD40 Ligand
Cell Differentiation
Female
Immunologic Memory
Ligands
Lymph Nodes
Lymphocyte Activation
Membrane Glycoproteins
Mice

Source

Open in PubMed

Identifiers

PMID: 7541819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7541819-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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