Article
Origins and functions of B-1 cells with notes on the role of CD5.
Annual review of immunology - 1 Jan 2002
Berland Robert, Wortis Henry H
Abstract excerpt
Whether B-1a (CD5+) cells are a distinct lineage derived from committed fetal/neonatal precursors or arise from follicular B-2 cells in response to BCR ligation and other, unknown signals remains controversial. Recent evidence indicates that B-1a cells can derive from adult precursors expressing an appropriate specificity when the (self-) antigen is present. Antibody specificity determines whether a B cell...
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