Article
Cleavage of Gag precursor is required for early replication phase of HIV-1.
FEBS letters - 29 Sept 1997
Kawamura M, Shimano R, Inubushi R, Amano K, Ogasawara T, Akari H, Adachi A
Abstract excerpt
A mutant of human immunodeficiency virus type 1 (HIV-1), which is deficient for Gag precursor cleavage and noninfectious, was characterized with respect to its defective step in the viral replication phase. Upon transfection, the mutant produced a normal level of progeny virions as monitored by electron microscopy and RNA hybridization. Single-round replication assay demonstrated, in contrast, that the mutant was...
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