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Article

HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.

The Journal of biological chemistry - 23 Oct 2009

Müller Barbara, Anders Maria, Akiyama Hisashi, Welsch Sonja, Glass Bärbel, Nikovics Krisztina, Clavel Francois, Tervo Hanna-Mari, Keppler Oliver T, Kräusslich Hans-Georg

Abstract excerpt

Protease inhibitors (PI) act by blocking human immunodeficiency virus (HIV) polyprotein processing, but there is no direct quantitative correlation between the degree of impairment of Gag processing and virion infectivity at low PI concentrations. To analyze the consequences of partial processing...

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Topics

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Share to gag Gene Products, Human Immunodeficiency Virus
Share to HIV Protease Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Reverse Transcriptase

Share to Protein Processing, Post-Translational

Share to Succinates

Share to Triterpenes

Share to Virus Internalization

Share to Virus Replication

Source

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Identifiers

PMID: 19666477
DOI: 10.1074/jbc.M109.027144
PMCID: PMC2785601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19666477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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