Article
Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation.
Virology - 1 May 1996
Quillent C, Borman A M, Paulous S, Dauguet C, Clavel F
Abstract excerpt
Human immunodeficiency type 1 particle maturation is dependent upon proteolytic cleavage of the gag and gag-pol precursors by the pol-encoded viral protease. We have investigated the importance of domains of pol other than the protease for particle maturation and gag proteolytic processing. Truncations of the gag-pol polyprotein precursor of HIV-1 were created by deleting segments of the reverse transcriptase...
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