Article
Extensive regions of pol are required for efficient human immunodeficiency virus polyprotein processing and particle maturation.
Virology - 1 May 1996
Quillent C, Borman A M, Paulous S, Dauguet C, Clavel F
Abstract excerpt
Human immunodeficiency type 1 particle maturation is dependent upon proteolytic cleavage of the gag and gag-pol precursors by the pol-encoded viral protease. We have investigated the importance of domains of pol other than the protease for particle maturation and gag proteolytic processing. Trunc...
Topics
- Cloning, Molecular
- Gene Products, gag
- Gene Products, pol
- HIV Protease
- HIV-1
- HeLa Cells
- Humans
- Mutation
- Protein Precursors
- Protein Processing, Post-Translational
- Proteins
- Virion
- Virus Assembly