Article
Antibodies to C1q in systemic lupus erythematosus: characteristics and relation to Fc gamma RIIA alleles.
Kidney international - 1 Nov 1997
Haseley L A, Wisnieski J J, Denburg M R, Michael-Grossman A R, Ginzler E M, Gourley M F, Hoffman J H, Kimberly R P, Salmon J E
Abstract excerpt
Autoantibodies to the collagen-like region of the first complement component (C1qAB) are found in patients with systemic lupus erythematosus (SLE), particularly those with renal disease. In a cohort of 46 SLE patients with diffuse proliferative glomerulonephritis, we found declining C1qAB titers in 77% of treatment responders and in only 38% of treatment non-responders (P < 0.03). To further characterize this...
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