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Article

Anti-DNA antibodies cross-react with C1q

5 Jul 2013

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disorder that involves multiple organ systems and typically presents as a chronic inflammatory disease. Antibodies to double-stranded (ds) DNA are present in approximately 70% of patients and form nucleic acid containing immune complexes which activate dendritic cells through engagement of toll-like receptors, leading to a pro-inflammatory, pro-immunogenic...

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Identifiers

PMID: 23834843
DOI: 10.1016/j.jaut.2013.06.002

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