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Article

C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2002

Miura-Shimura Yuko, Nakamura Kazuhiro, Ohtsuji Mareki, Tomita Hideaki, Jiang Yi, Abe Masaaki, Zhang Danqing, Hamano Yoshitomo, Tsuda Hiroshi, Hashimoto Hiroshi, Nishimura Hiroyuki, Taki Shinsuke, Shirai Toshikazu, Hirose Sachiko

Abstract excerpt

Much of the pathology of systemic lupus erythematosus (SLE) is caused by deposition of immune complexes (ICs) into various tissues, including renal glomeruli. Because clearance of ICs depends largely on early complement component C1q, homozygous C1q deficiency is a strong genetic risk factor in SLE, although it is rare in SLE patients overall. In this work we addressed the issue of whether genetic polymorphisms...

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PMID: 12133956
DOI: 10.4049/jimmunol.169.3.1334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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