Article
Fc gamma RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jun 2004
Bazilio Ana Paula, Viana Vilma S T, Toledo Rui, Woronik Viktoria, Bonfá Eloisa, Monteiro Renato C
Abstract excerpt
BACKGROUND: Fc gamma RIIa is a low affinity receptor that has two co-dominantly expressed alleles, R131 and H131, which differ in their ability to bind immunoglobulin G (IgG) subclasses. Cells expressing H131 bind more efficiently complexed IgG2 and IgG3 than those expressing the R131 variant. The Fc gamma RIIa polymorphism has been shown to be associated with lupus nephritis. Here we evaluated the relevance of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.