Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin.

The Journal of biological chemistry - 10 Jun 2005

Sidhu Ranjinder S, Clough Richard R, Bhullar Rajinder P

Abstract excerpt

Second messengers generated from membrane lipids play a critical role in signaling and control diverse cellular processes. Despite being one of the most evolutionarily conserved of all the phosphoinositide-specific phospholipase C (PLC) isoforms, a family of enzymes responsible for hydrolysis of the membrane lipid phosphatidylinositol bisphosphate, the mechanism of PLC-delta1 activation is still poorly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calmodulin
Share to Cytosol
Share to GTP Phosphohydrolases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Phosphates

Share to Phosphatidylinositols

Share to Two-Hybrid System Techniques

Share to Type C Phospholipases

Source

Identifiers

PMID: 15817490
DOI: 10.1074/jbc.M412966200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin.PMID 15817490Read ↗

Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.Semantic proximity Read ↗

A novel dimeric active site and regulation mechanism revealed by the crystal structure of iPLA <sub>2</sub> βSemantic proximity Read ↗

IPMK: A versatile regulator of nuclear signaling events.Semantic proximity Read ↗

The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes.Semantic proximity Read ↗

Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.Semantic proximity Read ↗

Structural determinants for phosphatidic acid regulation of phospholipase C-beta1.Semantic proximity Read ↗

A role for nuclear phospholipase Cbeta 1 in cell cycle control.Semantic proximity Read ↗

Calcium-dependent signalling in B-cell lymphomas.Semantic proximity Read ↗

RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation.Semantic proximity Read ↗

Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling.Semantic proximity Read ↗

Genetic Analysis of Calmodulin and Its Targets in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.