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Article

Structural requirements of phosphatidylinositol-specific phospholipase C delta 1 for enzyme activity.

European journal of biochemistry - 1 Apr 1993

Ellis M V, Carne A, Katan M

Abstract excerpt

Phosphatidylinositol-specific phospholipase C delta 1 isozyme of phosphoinositol-specific phospholipase C has been used for studies of structural requirements for the catalytic function. The enzyme was expressed in a bacterial system and purified to homogeneity. Using a combination of deletion mutant analysis and limited proteolysis, it was found that the large proportion of the molecule participated in formation...

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PMID: 8386625
DOI: 10.1111/j.1432-1033.1993.tb17767.x

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