Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity.

doi:10.1194/jlr.M050781

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Article

Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity.

Journal of lipid research - 1 Apr 2015

Favale Nicolás Octavio, Santacreu Bruno Jaime, Pescio Lucila Gisele, Marquez Maria Gabriela, Sterin-Speziale Norma Beatriz

Abstract excerpt

Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization. Particularly, SM is associated with detergent-resistant microdomains. We have previously shown that the adherens junction (AJ) complex, the relevant cell-cell adhesion structure involved in cell differentiation and tissue...

Topics

Adherens Junctions
Animals
Cadherins
Cell Differentiation
Cell Nucleus
Dogs
Dose-Response Relationship, Drug
Enzyme Inhibitors
Gene Expression Regulation, Enzymologic
Gene Knockdown Techniques
Madin Darby Canine Kidney Cells
Osmotic Pressure

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Phenotype

Sphingomyelins

Transferases (Other Substituted Phosphate Groups)

alpha Catenin

beta Catenin

Source

Open in PubMed Open full text

Identifiers

PMID: 25670801
DOI: 10.1194/jlr.M050781
PMCID: PMC4373737

Provenance

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