Article
Elimination of defective alpha-factor pheromone receptors.
Molecular and cellular biology - 1 Nov 1997
Jenness D D, Li Y, Tipper C, Spatrick P
Abstract excerpt
This report compares trafficking routes of a plasma membrane protein that was misfolded either during its synthesis or after it had reached the cell surface. A temperature-sensitive mutant form of the yeast alpha-factor pheromone receptor (ste2-3) was found to provide a model substrate for quality control of plasma membrane proteins. We show for the first time that a misfolded membrane protein is recognized at...
Topics
- Biological Transport
- Cell Compartmentation
- Cell Membrane
- Cloning, Molecular
- Fungal Proteins
- Models, Molecular
- Mutation
- Protein Conformation
- Protein Folding
- Receptors, Mating Factor
- Receptors, Peptide