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Article

Elimination of defective alpha-factor pheromone receptors.

Molecular and cellular biology - 1 Nov 1997

Jenness D D, Li Y, Tipper C, Spatrick P

Abstract excerpt

This report compares trafficking routes of a plasma membrane protein that was misfolded either during its synthesis or after it had reached the cell surface. A temperature-sensitive mutant form of the yeast alpha-factor pheromone receptor (ste2-3) was found to provide a model substrate for quality control of plasma membrane proteins. We show for the first time that a misfolded membrane protein is recognized at...

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Identifiers

PMID: 9343384
DOI: 10.1128/MCB.17.11.6236
PMCID: PMC232474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Elimination of defective alpha-factor pheromone receptors.PMID 9343384Read ↗

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.Semantic proximity Read ↗

Ubiquitination of the yeast a-factor receptor.Semantic proximity Read ↗

Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.Semantic proximity Read ↗

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.Semantic proximity Read ↗

The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors.Semantic proximity Read ↗

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.Semantic proximity Read ↗

Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis.Semantic proximity Read ↗

Yeast mutants affecting possible quality control of plasma membrane proteins.Semantic proximity Read ↗

Ubiquitin-independent entry into the yeast recycling pathway.Semantic proximity Read ↗

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors.Semantic proximity Read ↗

Golgi-to-late endosome trafficking of the yeast pheromone processing enzyme Ste13p is regulated by a phosphorylation site in its cytosolic domain.Semantic proximity Read ↗

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