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Article

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

The EMBO journal - 15 Jul 1994

Kölling R, Hollenberg C P

Abstract excerpt

We are investigating the transport and turnover of the multispanning membrane protein Ste6. The Ste6 protein is a member of the ABC-transporter family and is required for the secretion of the yeast mating pheromone a-factor. In contrast to the prevailing view that Ste6 is a plasma membrane protein, we found that Ste6 is mainly associated with internal membranes and not with the cell surface. Fractionation and...

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Identifiers

PMID: 8045256
DOI: 10.1002/j.1460-2075.1994.tb06627.x
PMCID: PMC395222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.PMID 8045256Read ↗

Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae.Semantic proximity Read ↗

Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae.Semantic proximity Read ↗

The internalization of yeast Ste6p follows an ordered series of events involving phosphorylation, ubiquitination, recognition and endocytosis.Semantic proximity Read ↗

Mutations affecting phosphorylation, ubiquitination and turnover of the ABC-transporter Ste6.Semantic proximity Read ↗

Control of Ste6 recycling by ubiquitination in the early endocytic pathway in yeast.Semantic proximity Read ↗

A family of small coiled-coil-forming proteins functioning at the late endosome in yeast.Semantic proximity Read ↗

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.Semantic proximity Read ↗

The deubiquitinating enzyme Ubp1 affects sorting of the ATP-binding cassette-transporter Ste6 in the endocytic pathway.Semantic proximity Read ↗

Elimination of defective alpha-factor pheromone receptors.Semantic proximity Read ↗

A striking quality control subcompartment in Saccharomyces cerevisiae: the endoplasmic reticulum-associated compartment.Semantic proximity Read ↗

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.Semantic proximity Read ↗

Saccharomyces cerevisiae STE11 may contribute to the stabilities of a scaffold protein, STE5, in the pheromone signaling pathway.Semantic proximity Read ↗

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