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Article

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors.

The Journal of cell biology - 1 Jul 1993

Davis N G, Horecka J L, Sprague G F

Abstract excerpt

The Saccharomyces cerevisiae a-factor receptor (STE3) is subject to two modes of endocytosis: a constitutive process that occurs in the absence of ligand and a regulated process that is triggered by binding of ligand. Both processes result in delivery of the receptor to the vacuole for degradation. Receptor mutants deleted for part of the COOH-terminal cytoplasmic domain are disabled for constitutive, but not...

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Identifiers

PMID: 8391002
DOI: 10.1083/jcb.122.1.53
PMCID: PMC2119599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors.PMID 8391002Read ↗

The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors.Semantic proximity Read ↗

Ubiquitin-independent entry into the yeast recycling pathway.Semantic proximity Read ↗

Ubiquitination of the yeast a-factor receptor.Semantic proximity Read ↗

Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors.Semantic proximity Read ↗

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.Semantic proximity Read ↗

Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeast.Semantic proximity Read ↗

Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane.Semantic proximity Read ↗

Elimination of defective alpha-factor pheromone receptors.Semantic proximity Read ↗

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.Semantic proximity Read ↗

Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export.Semantic proximity Read ↗

Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis.Semantic proximity Read ↗

Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype.Semantic proximity Read ↗

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