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Article

The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors.

Molecular biology of the cell - 1 Jul 1997

Givan S A, Sprague G F

Abstract excerpt

The Saccharomyces cerevisiae a-factor receptor (Ste3p) requires its C-terminal cytoplasmic tail for endocytosis. Wild-type receptor is delivered to the cell surface via the secretory pathway but remains there only briefly before being internalized and delivered to the vacuole for degradation. Receptors lacking all or part of the cytoplasmic tail are not subject to this constitutive endocytosis. We used the...

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Identifiers

PMID: 9243510
DOI: 10.1091/mbc.8.7.1317
PMCID: PMC276155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors.PMID 9243510Read ↗

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors.Semantic proximity Read ↗

Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane.Semantic proximity Read ↗

Ubiquitination of the yeast a-factor receptor.Semantic proximity Read ↗

Ubiquitin-independent entry into the yeast recycling pathway.Semantic proximity Read ↗

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.Semantic proximity Read ↗

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.Semantic proximity Read ↗

Visualization of receptor-mediated endocytosis in yeast.Semantic proximity Read ↗

Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis.Semantic proximity Read ↗

The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast.Semantic proximity Read ↗

Elimination of defective alpha-factor pheromone receptors.Semantic proximity Read ↗

AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction.Semantic proximity Read ↗

The ankyrin repeats and DHHC S-acyl transferase domain of AKR1 act independently to regulate switching from vegetative to mating states in yeast.Semantic proximity Read ↗

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