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Article

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.

Molecular and cellular biology - 1 Nov 1994

Schandel K A, Jenness D D

Abstract excerpt

When Saccharomyces cerevisiae a cells bind alpha-factor pheromone, the ligand is internalized and its binding sites are lost from the cell surface in a time-, energy-, and temperature-dependent manner. This report presents direct evidence for alpha-factor-induced internalization of cell surface receptors. First, membrane fractionation on Renografin density gradients indicated that the alpha-factor receptors were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 7935439
DOI: 10.1128/mcb.14.11.7245-7255.1994
PMCID: PMC359259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct evidence for ligand-induced internalization of the yeast alpha-factor pheromone receptor.PMID 7935439Read ↗

Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis.Semantic proximity Read ↗

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.Semantic proximity Read ↗

Ubiquitination of the yeast a-factor receptor.Semantic proximity Read ↗

Elimination of defective alpha-factor pheromone receptors.Semantic proximity Read ↗

Visualization of receptor-mediated endocytosis in yeast.Semantic proximity Read ↗

The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors.Semantic proximity Read ↗

Actin and fimbrin are required for the internalization step of endocytosis in yeast.Semantic proximity Read ↗

Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization.Semantic proximity Read ↗

The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization.Semantic proximity Read ↗

The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors.Semantic proximity Read ↗

The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein.Semantic proximity Read ↗

Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors.Semantic proximity Read ↗

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