Article
Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations.
Molecular & general genetics : MGG - 1 Sept 1997
Hovland P G, Tecklenberg M, Sclafani R A
Abstract excerpt
This article presents the identification and characterization of the PAK1 gene of Saccharomyces cerevisiae, and the biochemical characterization of the protein kinase activity that it encodes. Overexpression of the PAK1 gene product suppresses temperature-sensitive mutations of the poll (cdc 17) gene, which encodes DNA polymerase alpha. Overexpression and suppression can be achieved either by expressing PAK1 from...
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