An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae.

doi:10.1093/genetics/148.1.33

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Article

An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae.

Genetics - 1 Jan 1998

Flick J S, Thorner J

Abstract excerpt

The PLC1 gene product of Saccharomyces cerevisiae is a homolog of the delta isoform of mammalian phosphoinositide-specific phospholipase C (PI-PLC). We found that two genes (SPL1 and SPL2), when overexpressed, can bypass the temperature-sensitive growth defect of a plc1delta cell. SPL1 is identic...

Topics

Amino Acid Sequence
Base Sequence
Cyclin-Dependent Kinase Inhibitor Proteins
Cyclin-Dependent Kinases
Cyclins
Deoxyribodipyrimidine Photo-Lyase
Enzyme Inhibitors
Enzyme Repression
Epistasis, Genetic
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Molecular Sequence Data
Mutation

Source

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Identifiers

PMID: 9475719
DOI: 10.1093/genetics/148.1.33
PMCID: PMC1459775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9475719-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phosphates

Phosphatidylinositol Diacylglycerol-Lyase

Phosphoinositide Phospholipase C

Proteins