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Article

Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.

The Journal of biological chemistry - 17 Jul 1998

Sells M A, Barratt J T, Caviston J, Ottilie S, Leberer E, Chernoff J

Abstract excerpt

p21-activated kinases (PAKs) bind to and are activated by Rho family GTPases such as Cdc42 and Rac. Since these GTPases play key roles in regulating cell polarity, stress responses, and cell cycle progression, the ability of PAK to affect these processes has been examined. We previously showed that fission yeast pak1+ encodes an essential protein that affects mating and cell polarity. Here, we characterize a...

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PMID: 9660818
DOI: 10.1074/jbc.273.29.18490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.PMID 9660818Read ↗

Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.Semantic proximity Read ↗

Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.Semantic proximity Read ↗

The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway.Semantic proximity Read ↗

Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5.Semantic proximity Read ↗

The kelch repeat protein, Tea1, is a potential substrate target of the p21-activated kinase, Shk1, in the fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae.Semantic proximity Read ↗

Actin cytoskeleton organization regulated by the PAK family of protein kinases.Semantic proximity Read ↗

Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe.Semantic proximity Read ↗

The PAK family kinase Cla4 is required for budding and morphogenesis in Ustilago maydis.Semantic proximity Read ↗

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.Semantic proximity Read ↗

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.Semantic proximity Read ↗

Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.Semantic proximity Read ↗

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