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Article

Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.

The Journal of biological chemistry - 17 Jul 1998

Sells M A, Barratt J T, Caviston J, Ottilie S, Leberer E, Chernoff J

Abstract excerpt

p21-activated kinases (PAKs) bind to and are activated by Rho family GTPases such as Cdc42 and Rac. Since these GTPases play key roles in regulating cell polarity, stress responses, and cell cycle progression, the ability of PAK to affect these processes has been examined. We previously showed th...

Topics

Amino Acid Sequence
Binding Sites
Cell Cycle Proteins
Enzyme Activation
GTP-Binding Proteins
Molecular Sequence Data
Phenotype
Protein Serine-Threonine Kinases
Saccharomyces cerevisiae Proteins
Schizosaccharomyces
Schizosaccharomyces pombe Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

cdc42 GTP-Binding Protein, Saccharomyces cerevisiae

p21-Activated Kinases

Source

Identifiers

PMID: 9660818
DOI: 10.1074/jbc.273.29.18490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9660818-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.PMID 9660818Read ↗

Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.Semantic proximity Read ↗

Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.Semantic proximity Read ↗

The Schizosaccharomyces pombe Cdc42p GTPase signals through Pak2p and the Mkh1p-Pek1p-Spm1p MAP kinase pathway.Semantic proximity Read ↗

Direct activation of the fission yeast PAK Shk1 by the novel SH3 domain protein, Skb5.Semantic proximity Read ↗

The kelch repeat protein, Tea1, is a potential substrate target of the p21-activated kinase, Shk1, in the fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae.Semantic proximity Read ↗

Actin cytoskeleton organization regulated by the PAK family of protein kinases.Semantic proximity Read ↗

Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe.Semantic proximity Read ↗

The PAK family kinase Cla4 is required for budding and morphogenesis in Ustilago maydis.Semantic proximity Read ↗

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.Semantic proximity Read ↗

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.Semantic proximity Read ↗

Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.Semantic proximity Read ↗

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