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The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein.

Molecular and cellular biology - 1 Jul 1997

Wittmeyer J, Formosa T

Abstract excerpt

We have used DNA polymerase alpha affinity chromatography to identify factors involved in eukaryotic DNA replication in the yeast Saccharomyces cerevisiae. Two proteins that bound to the catalytic subunit of DNA polymerase alpha (Pol1 protein) are encoded by the essential genes CDC68/SPT16 and POB3. The binding of both proteins was enhanced when extracts lacking a previously characterized polymerase binding...

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Identifiers

PMID: 9199353
DOI: 10.1128/MCB.17.7.4178
PMCID: PMC232271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein.PMID 9199353Read ↗

POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo.Semantic proximity Read ↗

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.Semantic proximity Read ↗

Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.Semantic proximity Read ↗

Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.Semantic proximity Read ↗

Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress.Semantic proximity Read ↗

The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing.Semantic proximity Read ↗

RNA Polymerase II Elongation Factors of <i>Saccharomyces cerevisiae</i>: a Targeted Proteomics ApproachSemantic proximity Read ↗

The Saccharomyces cerevisiae protein YJR043C (Pol32) interacts with the catalytic subunit of DNA polymerase alpha and is required for cell cycle progression in G2/M.Semantic proximity Read ↗

Mutations in SPT16/CDC68 suppress cis- and trans-acting mutations that affect promoter function in Saccharomyces cerevisiae.Semantic proximity Read ↗

A coordinated temporal interplay of nucleosome reorganization factor, sister chromatin cohesion factor, and DNA polymerase alpha facilitates DNA replication.Semantic proximity Read ↗

New mutant versions of yeast FACT subunit Spt16 affect cell integrity.Semantic proximity Read ↗

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