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Article

Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype.

Journal of neuropathology and experimental neurology - 1 Oct 2003

Causevic Mirsada, Ramoz Nicolas, Haroutunian Vahram, Davis Kenneth L, Buxbaum Joseph D

Abstract excerpt

The low-density lipoprotein receptor-related protein (LRP), which interacts with the Alzheimer disease (AD) beta-amyloid precursor protein (APP), represents an important pathway in AD pathology. LRP-mediated receptor pathways appear to regulate both the production and the clearance of amyloid beta-protein (Abeta), a principal neuropathological product in AD. Several conflicting studies have examined levels of LRP...

Topics

Alzheimer Disease
Blotting, Western
Brain
Brain Chemistry
Cohort Studies
Cysteine
Exons
Genotype
Glyceraldehyde-3-Phosphate Dehydrogenases
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Low Density Lipoprotein Receptor-Related Protein-1

Polymorphism, Genetic

Threonine

Source

Identifiers

PMID: 14575236
DOI: 10.1093/jnen/62.10.999

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype.PMID 14575236Read ↗

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LRP3, an apolipoprotein receptor that links reelin signalling and APP expression, is affected in Alzheimer's diseaseSemantic proximity Read ↗

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