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Article

Transforming growth factor beta peptide antagonists and their conversion to partial agonists.

The Journal of biological chemistry - 24 Oct 1997

Huang S S, Liu Q, Johnson F E, Konish Y, Huang J S

Abstract excerpt

Transforming growth factor beta (TGF-beta) has been implicated in the pathogenesis of various human diseases. Synthetic TGF-beta antagonists therefore could have therapeutic utility. Here we show the development of such compounds. Three synthetic pentacosapeptides designated beta125-(41-65), beta225-(41-65), and beta325-(41-65), whose amino acid sequences correspond to the 41st to 65th amino acid residues of...

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PMID: 9341157
DOI: 10.1074/jbc.272.43.27155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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