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Article

Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex.

The Journal of biological chemistry - 28 May 2010

Walton Kelly L, Makanji Yogeshwar, Chen Justin, Wilce Matthew C, Chan Karen L, Robertson David M, Harrison Craig A

Abstract excerpt

Transforming growth factor-beta1 (TGF-beta1) is secreted as part of an inactive complex consisting of the mature dimer, the TGF-beta1 propeptide (latency-associated peptide (LAP)), and latent TGF-beta-binding proteins. Using in vitro mutagenesis, we identified the regions of LAP that govern the cooperative assembly and stability of the latent TGF-beta1 complex. Initially, hydrophobic LAP residues (Ile(53),...

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Identifiers

PMID: 20308061
DOI: 10.1074/jbc.M110.110288
PMCID: PMC2878044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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