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Transforming growth factor beta mimetics: discovery of 7-[4-(4-cyanophenyl)phenoxy]-heptanohydroxamic acid, a biaryl hydroxamate inhibitor of histone deacetylase.

Molecular cancer therapeutics - 1 Aug 2002

Glaser Keith B, Li Junling, Aakre Mary E, Morgan Douglas W, Sheppard George, Stewart Kent D, Pollock Jennifer, Lee Paul, O'Connor Chad Z, Anderson Steven N, Mussatto Donna J, Wegner Craig W, Moses Harold L

Abstract excerpt

Transforming growth factor beta (TGF-beta) is a multifunctional protein that has been shown to possess potent growth-inhibitory activity. To identify small molecular weight compounds with TGF-beta-like activities, high throughput screening was performed using mink lung epithelial cells stably transfected with a TGF-beta-responsive plasminogen activator inhibitor 1 promoter/luciferase construct. Biaryl hydroxamate...

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PMID: 12492108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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