Article
Identification of amino acid residues that form part of the ligand-binding pocket of integrin alpha5 beta1.
The Journal of biological chemistry - 2 Oct 1998
Mould A P, Burrows L, Humphries M J
Abstract excerpt
Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J. Cell Biol. 124, 373-380). Here we have localized the binding site for RRETAWA on alpha5 b...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Binding Sites
- Binding, Competitive
- Cations, Divalent
- Cell Adhesion
- Epitopes
- Fibronectins
- Humans
- Ligands
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oligopeptides
- Peptide Fragments
- Protein Binding