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Article

Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms.

Molecular and cellular biology - 1 Apr 1992

Lopez A R, Cook J, Deininger P L, Derynck R

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is a secreted polypeptide factor that is thought to play a major role in the regulation of proliferation of many cell types and various differentiation processes. Several related isoforms have been structurally characterized, three of which, TGF-beta 1, -beta 2, and -beta 3, have been detected in mammalian cells and tissues. Each TGF-beta form is a homodimer of a...

Topics

Biological Transport, Active
Cell Line
Gene Expression
Genes, Dominant
Genetic Variation
Humans
Mutagenesis, Site-Directed
Mutation
Protein Precursors
Protein Sorting Signals
Transforming Growth Factor beta

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Identifiers

PMID: 1549120
DOI: 10.1128/mcb.12.4.1674-1679.1992
PMCID: PMC369610

Genes

TFG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1549120-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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