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Article

Inhibitors of the TGF-β Superfamily and their Clinical Applications

28 Oct 2006

Abstract excerpt

The transforming growth factor-beta (TGF-beta) superfamily includes TGF-betas, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-beta family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-beta superfamily regulate fine-tuning of activity of TGF-beta family in vivo. In addition to...

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PMID: 17100637
DOI: 10.2174/138955706778742759

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