Article
Two divergent signaling pathways for TGF-beta separated by a mutation of its type II receptor gene.
Biochemical and biophysical research communications - 7 Jun 1999
Lu S L, Kawabata M, Imamura T, Miyazono K, Yuasa Y
Abstract excerpt
Transforming growth factor beta (TGF-beta) can inhibit epithelial cell growth and induce extracellular matrix formation through signal transduction via its two receptors and its downstream intracellular Smad proteins. We recently reported a germline mutation, i.e., substitution of methionine for threonine at codon 315 in the kinase subdomain IV, of the TGF-beta type II receptor gene in a kindred of hereditary...
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